![]() Received: MaAccepted: JPublished: August 21, 2013Ĭopyright: © 2013 Uchiya et al. PLoS ONE 8(8):Įditor: Olivier Neyrolles, Institut de Pharmacologie et de Biologie Structurale, France (2013) Comparative Genome Analysis of Mycobacterium avium Revealed Genetic Diversity in Strains that Cause Pulmonary and Disseminated Disease. avium strains that cause pulmonary and disseminated disease possess genetically distinct features, and it suggests that the acquisition of specific genes during strain evolution has played an important role in the pathological manifestations of MAC disease.Ĭitation: Uchiya K-i, Takahashi H, Yagi T, Moriyama M, Inagaki T, Ichikawa K, et al. Screening of clinical isolates for genes located in the strain-specific regions revealed that the detection rates of strain TH135-specific genes were relatively high in specimens isolated from pulmonary MAC disease patients, while, those of strain 104-specific genes were relatively high in those from HIV-positive patients. Many strain-specific regions including virulence-associated genes were found in genomes of both strains, and except for some regions, the G+C content in the specific regions was low compared with the mean G+C content of the corresponding chromosome. Comparative analysis revealed that 4,012 genes are shared between the two strains, and strains TH135 and 104 have 624 and 1,108 unique genes, respectively. The genome of strain TH135 consists of a 4,951,217-bp circular chromosome with 4,636 coding sequences. avium strain 104 derived from an acquired immunodeficiency syndrome patient with MAC disease. hominissuis strain TH135 isolated from a HIV-negative patient with pulmonary MAC disease and compared it with the known genomic sequence of M. avium, we determined the complete genome sequence of the previously unreported M. To explore the bacterial factors that affect the pathological state of MAC disease caused by M. avium is about 7 times higher than that caused by M. In Japan, the incidence of pulmonary MAC disease caused by M. Mycobacterium avium complex (MAC) infection causes disseminated disease in immunocompromised hosts, such as human immunodeficiency virus (HIV)-positive patients, and pulmonary disease in persons without systemic immunosuppression, which has been increasing in many countries.
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